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Asacol, which is mesalamine - derivative of 5-aminosalicylic acid. It is prsecribed for treatment and remission maintenance at patients with ulcer colitis (earlier known as nonspecific ulcer colitis) of mild and moderate type.
- Eilenburg
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- Holzminden
- Bebra
- Geringswalde
Mesalamine for microscopic colitis
In a recent Cochrane review of the effects sulpizine versus placebo (also known as Xalatan) in patients with chronic ulcerative colitis (UC), researchers looked at data on ulcerative colitis trials conducted over a period of nearly 20 years, which evaluated the effectiveness of placebo and sulpizine in over 1,400 patients with UC. The authors also examined results from an ongoing phase III trial involving 3,071 patients. This particular trial is ongoing, however, and did not include patients with Crohn's disease, because a meta-analysis of previous studies had found little or no benefit of the sulpiride (Xalatan) in this condition. The authors concluded:
"…the benefit of placebo or sulpiride in ulcerative colitis appears to be modest, even after adjustment for clinical and epidemiologic differences between treatment groups. The overall effect of these agents appears small." (Bhatia J, et al. A randomized, double blind, placebo/xalatan double-blinded, trial in chronic non-ulcerative colitis. Cochrane Database Syst Rev. 2011 Mar 6 [epub ahead of print]).
Sulprides are effective only in the treatment of ulcerative colitis
In a recent Cochrane review of four other studies that compared sulphasalazine at doses of 3 to 500 mg daily with placebo, the authors concluded following:
"In summary, results from a total of eight studies sulphasalazine in patients with irritable bowel disease or IBS, showed either a non-significant reduction in mean weekly relapse rat